Test Your Knowledge


Choose the best answer based on your reading of Module 5

  1. Which new scientific stem cell based innovation may have been a direct result of President Bush’s ban on the funding of embryonic stem cell research?
    1. Somatic Cell Nuclear Transfer
    2. Induced Pluripotent Stem Cells (iPS)
    3. Cloning
    4. None of the above

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  2. What was the key factor in President Bush’s restriction on embryonic stem cell research?
    1. The high cost and the inefficiency of the experiment
    2. The high risk factors of the experiment
    3. The bioethical issues associated with the destruction of human embryos
    4. The ethical concerns raised by the religious institutions

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  3. Who was the first scientist credited to develop iPS?
    1. Hwang Woo-suk
    2. Shinya Yamanaka
    3. Jackie Chan
    4. An unacknowledged graduate student at Columbia University

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  4. What are the four transcription factors involved in iPS/
    1. OCT4, SOX2, c-Myc, and KLF4
    2. Klf4, MYC, SOX2, and OCT4
    3. OCT4, SOX2, c-Myc, and NANOG
    4. NANOG, OCT3/4, MYC, SOX2

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  5. Which factor plays a crucial role in maintaining pluripotency in pluripotent stem cells?
    1. SOX2
    2. Klf4
    3. c-Myc
    4. OCT4
    5. Not clear at this time

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  6. What is the main hurdle in transfecting these genes into adult cells?
    1. Tissue rejection
    2. Formation of cancer-like cell due to the present of oncogene in c-Myc
    3. Auto immunity
    4. None of the above

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  7. Which interventions can be used to prevent tumor formation resulting from transplanting stem cells into animals?
    1. Use gene vectors that do not integrate into the host cell genome
    2. Integrate vectors in the genome with the capacity to subsequently remove them from the genome
    3. Providing the animals with a cocktail of anti-cancer drugs
    4. Both 1 and 2

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  8. What is the best scientific and ethically acceptable method used to generate human pluripotent stem cells without any genetic alteration of adult cell?
    1. SCNT
    2. iPSC
    3. piPSC
    4. None of the above

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  9. What are the most important parameters used to compare iPS cells to ESC?
    1. Morphology and growth properties
    2. Stem cell genes and the surface markers
    3. Telomerase activity
    4. All of the above

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  10. What is the major challenge(s) in reprogramming iPS generation?
    1. The pluripotency of the cell
    2. The low efficiency (0.01- 0.1%) of iPS generation
    3. Both of the above
    4. None of the above

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