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Introduction
Modules
1. The Biology of Stem Cells
2. Introduction to Stem Cell Bioethics
3. Cellular Differentiation
4. Somatic Cell Nuclear Transfer
5. Induced Pluripotent Cells
6. Human Hematopoietic System
7. Human-Animal Chimeras
8. Applications of Stem Cell Science
Conclusion
Course Glossary
Current Issues (RSS)
Course Bibliography and Resources
Acknowledgements
About
Supplements
1. Legal History of Stem Cell Science
2. Animal Rights and Welfare
3. Historical Overview of Vertebrate Cloning
4. Ethical Considerations of Egg Donation
5. The Hwang Cloning Scandal
6. Research Ethics and Clinical Trials
7. The Commercialization of Stem Cells
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Table of Contents
Introduction
What are stem cells?
Totipotency and Pluripotency
Generating Embryonic Stem Cells In Vitro
Early Historical Origins of Stem Cell biology
Classification and Sources of Stem Cells
Isolation and Purification of Stem Cells
iPS technology
Comparing Stem Cell Sources
Conclusion
Test Your Knowledge
References
Test Your Knowledge
Choose the best answer based on your reading of Module 1
What defines stem cells?
Cells that can transform into any type of cell, such as blood, muscle, or skin cells.
Cells that are obtained from the inner mass of a pre-implanted embryo thereby destroying the embryo.
Cells that have the ability to renew themselves continuously.
All of the above.
4. All of the above.
Check answer
Who was the first scientist to conceive the idea of cellular differentiation?
Theodor Schwann
Robert Hooke
Alexander Maksimov
John Enders
1. Theodor Schwan
Check answer
What are the near term clinical applications of stem cells?
To replace or repair injured cells in patients
To be used to in organ regeneration
To make human clones after an individual accidently dies
Only 1 and 2
4. Only 1 and 2
Check answer
What are the broad categories of stem cells?
Adult, embryonic and umbilical cord stem cell
Totipotent, Pluripotent, and Multipotent stem cell
Both 1and 2
None of the above
2. Totipotent, Pluripotent, and Multipotent stem cell
Check answer
What is a pluripotent stem cell?
Cells found in the inner mass of blastocyst that can differentiate into over 200 different cell types except placental cells
Stem cells derived from adult tissue, cord blood, and bone marrow and that do not differentiate into all the different cell types
Any progenitor cell found in human embryos
None of the above
1. Cells found in the inner mass of blastocyst that can differentiate into over 200 different cell types except placental cells
Check answer
What is the gold standard “stem cell”?
Fertilized human egg
Stem cells obtained from the inner mass of embryos
Stem cells obtained from umbilical cord blood
Stem cells obtained from bone marrow
1. Fertilized human egg
Check answer
What does pluripotency mean?
Self-renewal property of the cell
The ability to transform into any type of cell
The ability to form tumors
None of the above
2. The ability to transform into any type of cell
Check answer
What stem cell technology requires the transfection of cells with the following four genes - Oct4, Sox2, Klf4, c-Myc?
Induced Pluripotent System (iPS)
Somatic Cell Nuclear Transfer (SCNT)
Cloning
None of the above
1. Induced Pluripotent System (iPS)
Check answer
Who is credited with discovering and developing iPS technology?
Shinyi Yamanaka
John Gearhart
John Enders
Charles Darwin
1. Shinyi Yamanaka
Check answer
What is the scientific challenge in developing a new therapy based upon embryonic stem cell replacement?
Tissue rejection and tumor formation
Hard to harvest
Slow to proliferate
None of the above
1. Tissue rejection and tumor formation
Check answer
Approximately how many embryonic stem cell lines are federally approved (as of 2011)?
20
100
65
93
4. 93
Check answer
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Test Your Knowledge
Choose the best answer based on your reading of Module 1Click here to return to Module 1 - The Biology of Stem Cells